Rhinitis and eosinophilic inflammation are prevalent in both allergic and non-allergic asthma
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چکیده
منابع مشابه
Eosinophilic Inflammation in Allergic Asthma
Eosinophils are circulating granulocytes involved in pathogenesis of asthma. A cascade of processes directed by Th2 cytokine producing T-cells influence the recruitment of eosinophils into the lungs. Furthermore, multiple elements including interleukin (IL)-5, IL-13, chemoattractants such as eotaxin, Clara cells, and CC chemokine receptor (CCR)3 are already directly involved in recruiting eosin...
متن کاملEosinophilic inflammation in allergic rhinitis and nasal polyposis.
On histopathological examination, nasal polyps and nasal mucosa in allergic rhinitis show different forms of pseudostratified respiratory epithelium, whereas the dominant characteristic of lamina propria is an eosinophilic infiltration. The aim of this study was to compare interleukin (IL)-5 and eosinophilic cationic protein (ECP) levels in the nasal fluid of 42 patients: 12 with allergic rhini...
متن کاملEarly phase resolution of mucosal eosinophilic inflammation in allergic rhinitis
BACKGROUND It is widely assumed that apoptosis of eosinophils is a central component of resolution of allergic airway disease. However, this has not been demonstrated in human allergic airways in vivo. Based on animal in vivo observations we hypothesised that steroid-induced resolution of human airway eosinophilic inflammation involves inhibition of CCL5 (RANTES), a CC-chemokine regulating eosi...
متن کاملAllergic rhinitis and asthma: inflammation in a one-airway condition
BACKGROUND Allergic rhinitis and asthma are conditions of airway inflammation that often coexist. DISCUSSION In susceptible individuals, exposure of the nose and lungs to allergen elicits early phase and late phase responses. Contact with antigen by mast cells results in their degranulation, the release of selected mediators, and the subsequent recruitment of other inflammatory cell phenotype...
متن کاملSerum Level of Selenium, IL-4, IL-10 & IFN-g in Patients with Allergic Asthma, Allergic Rhinitis and Healthy Controls
Background: Allergic diseases have increased during the past decade worldwide. Th2 type lymphocyte response is known to play an important role in the process of allergic inflammation. IL-4, a mediator of type II cytokine response increases IgE synthesis and Interferon gamma, a cytokine of type I response interferes with IL-4 and inhibits IgE production. Selenium is an essential component of glu...
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ژورنال
عنوان ژورنال: World Allergy Organization Journal
سال: 2020
ISSN: 1939-4551
DOI: 10.1016/j.waojou.2020.100187